Related Experiment Video
Updated: Jun 10, 2026

08:19
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Nampt/PBEF/visfatin and cancer
1Department of General Surgery, The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Cancer Biology & Therapy
|July 22, 2010
Summary
Nicotinamide phosphoribosyltransferase (Nampt) is crucial for NAD+ biosynthesis and cancer cell growth. Inhibitors of Nampt are being explored as potential anticancer therapeutics targeting cancer progression.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Nampt (Nicotinamide phosphoribosyltransferase), also known as PBEF or visfatin, is the rate-limiting enzyme in NAD+ biosynthesis.
- It plays a role in regulating mammalian cell growth, apoptosis, and angiogenesis.
- Nampt was initially identified as a cytokine that promotes B cell maturation.
Purpose of the Study:
- To review the role of Nampt in carcinogenesis and cancer progression.
- To discuss Nampt inhibitors as potential therapeutic targets for cancer treatment.
Main Methods:
- Literature review focusing on Nampt's function in cancer.
- Analysis of signaling pathways regulated by Nampt, including PI3K/Akt, ERK1/2, and STAT3.
- Examination of clinical evaluations of Nampt inhibitors like FK866/APO866 and CHS828/GMX1777.
Main Results:
- Elevated Nampt expression is observed in various cancers.
- Nampt influences key signaling pathways implicated in cancer development and progression.
- Clinical trials have investigated Nampt inhibitors as anticancer agents.
Conclusions:
- Nampt is a significant factor in cancer development and progression.
- Targeting Nampt with inhibitors represents a promising therapeutic strategy for cancer treatment.
![Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F68356.jpg&w=3840&q=50)
