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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

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Updated: Jun 10, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Circadian rhythms and memory formation.

Jason R Gerstner1, Jerry C P Yin

  • 1Department of Genetics, University of Wisconsin-Madison, 3476 Genetics and Biotechnology, 425 Henry Mall, Madison, Wisconsin 53706, USA. jrgerstn@gmail.com

Nature Reviews. Neuroscience
|July 22, 2010
PubMed
Summary
This summary is machine-generated.

Circadian rhythms and long-term memory formation share common molecular mechanisms. Understanding this link may reveal new ways to enhance memory persistence and cognitive function.

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Last Updated: Jun 10, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
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Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Chronobiology

Background:

  • Significant progress has been made in understanding memory formation and circadian rhythms independently.
  • The interaction between circadian rhythms and long-term memory generation remains poorly understood.
  • Recent research indicates time-of-day influences on neurophysiology and memory.

Purpose of the Study:

  • To investigate the interplay between circadian rhythmicity and long-term memory formation.
  • To explore the role of molecular mechanisms in linking these two processes.
  • To synthesize findings from vertebrate and invertebrate models.

Main Methods:

  • Review of recent studies in vertebrate and invertebrate models.
  • Analysis of time-of-day effects on neurophysiology.
  • Investigation of molecular mechanisms in memory persistence.

Main Results:

  • Evidence suggests time-of-day significantly impacts neurophysiology and memory formation.
  • Cycling molecules appear to play a role in the persistence of long-term memory.
  • Common underlying mechanisms for circadian rhythms and long-term memory are indicated.

Conclusions:

  • Circadian rhythmicity and long-term memory formation likely share common molecular underpinnings.
  • Further research into these shared mechanisms could offer insights into memory enhancement.
  • This understanding has implications for cognitive function and neurological disorders.