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Updated: Jun 10, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
[Hydrogen magnetic resonance quantitative spectroscopy at 3 T in symptomatic and asymptomatic Huntington's disease
Sarael Alcauter-Solórzano1, Erick H Pasaye-Alcaraz, Patricia Alvarado-Alanis
1Posgrado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Querétaro, QRO, México.
Introduction:
Huntington's disease is an hereditary autosomic-dominant neurodegenerative disorder, characterized by motor, cognitive and psychiatric symptoms.
Aim:
To quantify differences in N-acetylaspartate, creatine and choline in caudate nucleus, putamen and occipital cortex of patients with Huntington's disease, symptomatics and asymptomatics.
Subjects And Methods:
Hydrogen magnetic resonance spectroscopy was performed with a 3 T scanner in 10 Huntington's disease gene-tested subjects, included in three groups: negative (control), positive symptomatics and positive asymptomatics. Data was quantified with LCModel and analyzed with ANOVA and Fisher tests.
Results:
Symptomatic patients showed decreased creatine and N-acetylaspartate in the three regions, and decreased choline only in putamen (p < 0.05). Choline difference was found between symptomatics and asymptomatics in the caudate nucleus (p < 0.05).
Conclusions:
Results may reflect neuronal dysfunction and suggest that creatine and choline may serve as markers for Huntington's disease progression.
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