Related Experiment Video

Updated: Jun 10, 2026

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

[Intracranial propagation of invasive aspergilloma in an immuncompromised patient]

Márta Simon1, Ildikó Vastagh, György Várallyay

  • 1Semmelweis Egyetem, Neurológiai Klinika, Budapest.

Ideggyogyaszati Szemle
|July 23, 2010
PubMed

Insights

Central nervous system Aspergillus infection is rare in immunocompromised individuals. This case highlights invasive aspergilloma presenting as cavernous sinus syndrome, emphasizing opportunistic CNS infections in immunocompromised patients.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Medical Mycology

Background:

  • Central nervous system (CNS) Aspergillus infections are uncommon, primarily affecting immunocompromised patients via hematogenic spread.
  • Direct spread from paranasal sinuses is less frequent and typically seen in immunocompetent individuals.

Observation:

  • A patient undergoing prolonged chemotherapy and steroid therapy for chronic lymphoid leukemia and immunhemolytic anemia developed cavernous sinus syndrome.
  • Radiological imaging (CT and MRI) suggested invasive intracranial aspergilloma.

Findings:

  • Postoperative histology confirmed invasive intracranial aspergilloma as the cause of cavernous sinus syndrome.
  • This case illustrates a rare presentation of opportunistic CNS infection in an immunocompromised host.

Implications:

  • Clinicians should consider invasive opportunistic CNS infections, such as aspergilloma, in immunocompromised patients with new neurological deficits.
  • Early diagnosis and treatment are crucial for managing invasive fungal CNS infections.

More Related Videos

Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions09:42

Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions

Published on: May 16, 2020

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...