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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Published on: October 4, 2019

The C19-diterpenoid alkaloids.

Feng-Peng Wang1, Qiao-Hong Chen

  • 1Department of Chemistry of Medicinal Natural Products, West China of Pharmacy, Sichuan University, Chengdu, People's Republic of China. wfp@scu.edu.cn

The Alkaloids. Chemistry and Biology
|July 24, 2010
PubMed
Summary
This summary is machine-generated.

This review details C19-diterpenoid alkaloids, covering their chemistry, distribution, biosynthesis, and pharmacology over 30 years. It provides a comprehensive profile of these complex natural products.

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Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • Diterpenoid alkaloids are a large, complex class of natural products.
  • C19-diterpenoid alkaloids are of significant research interest due to their diverse bioactivities and intricate chemistry.

Purpose of the Study:

  • To systematically summarize 30 years of research on C19-diterpenoid alkaloids.
  • To provide a comprehensive profile of these compounds, complementing previous reviews on related alkaloids.

Main Methods:

  • Literature review of studies over the past 30 years.
  • Compilation of data on classification, distribution, biogenesis, biosynthesis, phytochemotaxonomy, spectral properties, X-ray analysis, chemical reactions, and pharmacological activities.

Main Results:

  • Extensive data on C19-diterpenoid alkaloids is systematically presented.
  • Covers classification, distribution, biosynthesis, spectral properties, chemical conversions, and pharmacological effects.
  • Highlights applications in the phytochemotaxonomy of Chinese Aconitum L.

Conclusions:

  • This review offers an updated and complete profile of C19-diterpenoid alkaloids.
  • It serves as a valuable resource for researchers in natural product chemistry and pharmacology.
  • Further research on total synthesis will be covered in a separate chapter.