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Computer-assisted image analysis of skin surface replicas.

R Murphy1, D W Cotton, A L Wright

  • 1University Department of Pathology, Royal Hallamshire Hospital, Sheffield, U.K.

The British Journal of Dermatology
|June 1, 1991
PubMed
Summary
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This study introduces a novel method using dental impression material and computer analysis to quantitatively assess skin topography. The technique reveals that skin surface markings originate in the dermis and aids in studying conditions like eczema.

Area of Science:

  • Dermatology
  • Biomedical Engineering
  • Surface Science

Background:

  • Understanding skin surface topography is crucial for diagnosing and treating various dermatological conditions.
  • Existing methods for analyzing skin surface morphology have limitations in quantitative assessment and spatial resolution.

Purpose of the Study:

  • To develop and validate a novel, quantitative method for analyzing skin surface topography using dental impression material and computer-assisted image analysis.
  • To investigate the origin of skin surface markings and their changes during healing processes.

Main Methods:

  • Negative skin surface impressions were created using a rubber-based dental material.
  • Specimens were analyzed using scanning electron microscopy and a computer-assisted image analyzer for quantitative topographical assessment.

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  • The technique was applied to study experimental trauma (tape stripping), eczema resolution, and steroid treatment effects.

    • Main Results:

    • The developed technique quantitatively characterized skin topography based on geometric subunits, particularly effective on hair-bearing surfaces.
    • Skin surface markings were identified as originating from the dermis.
    • The method allowed for the observation of skin healing after tape stripping and the effects of eczema and steroid treatment.

    Conclusions:

    • Dental impression material combined with computer-assisted image analysis offers a reliable and quantitative method for skin topography assessment.
    • This technique provides insights into the dermal origin of skin markings and their dynamic changes in response to trauma and treatment.