Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interferon-λ drives renal fibrosis by coordinating epithelial-fibroblast crosstalk.

The Journal of experimental medicine·2026

Same author

Cardiovirus-Mediated PKR inhibition results from nucleocytoplasmic trafficking disruption.

PLoS pathogens·2025

Same author

A simple workflow to identify novel small linear motif (SLiM)-mediated interactions with AlphaFold.

Briefings in bioinformatics·2025

Same author

The leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex.

Journal of virology·2025

Same author

The "DDVF" motif used by viral and bacterial proteins to hijack RSK kinases mimics a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway.

PLoS pathogens·2025

Same author

Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice.

Journal of virology·2025

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

What have we learned from the IL28 receptor knockout mouse?

Markus Mordstein¹, Thomas Michiels, Peter Staeheli

¹Department of Virology, University of Freiburg, Freiburg, Germany.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research

|July 24, 2010

Summary

Type III interferons (IFNs), or IFN-lambda, are crucial for innate immunity against viruses. Studies using IL28Ralpha(0/0) mice reveal their in vivo antiviral role and identify specific receptor-expressing cells.

More Related Videos

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4⁺CD45RB^high T Cells into Immunodeficient Mice

Published on: April 21, 2015

Related Experiment Videos

Last Updated: Jun 10, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4⁺CD45RB^high T Cells into Immunodeficient Mice

Published on: April 21, 2015

Area of Science:

Immunology
Virology
Molecular Biology

Background:

Type III interferons (IFNs), also known as IFN-lambda, are key components of the innate immune response to viral infections.
While similar to type I IFNs (IFN-alpha/beta) in signaling pathways, IFN-lambda utilizes a distinct receptor complex (IL28R) with limited cell-type expression.
The in vivo role of IFN-lambda in antiviral resistance and the specific locations of IL28R-expressing cells were previously unclear.

Purpose of the Study:

To elucidate the contribution of type III interferons (IFNs) to antiviral defense in vivo.
To identify the specific cell types expressing functional IFN-lambda receptors across various organs.

Main Methods:

Utilized experiments involving IL28Ralpha(0/0) knockout mice to assess IFN-lambda's in vivo antiviral functions.
Conducted experiments to map the expression patterns of functional IFN-lambda receptors in different tissues.

Main Results:

Data from IL28Ralpha(0/0) mice demonstrated a significant role for IFN-lambda in controlling viral infections in vivo.
Experiments successfully identified specific cell populations in various organs that express functional IFN-lambda receptors.

Conclusions:

Type III interferons (IFNs) play a critical role in host defense against viral pathogens.
Understanding the specific cellular distribution of IFN-lambda receptors is essential for comprehending its immune functions.