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Morphological effects of the catechol estrogens on rat epididymal epithelia
J C Seegers1, L B Nieuwoudt, W S Joubert
1Department of Physiology, Faculty of Medicine, University of Pretoria, South Africa.
Abstract:
The 2-hydroxy and 4-hydroxyestradiols (2-/4-OHE2) caused marked cytotoxic effects, including vacuolation and nuclear changes, in rat epididymal epithelia, after exposure to very low levels (40 ng/rat/week) for 20 weeks. The effects of the 2-/4-OHE2 metabolites were more pronounced than that of estradiol-17 beta (E2).