Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluating the Roth and Dyspnea severity score for emergency department discharge in exacerbations of chronic obstructive pulmonary disease.

The American journal of emergency medicine·2026

Same author

Dose-Response and survival analysis after transarterial radioembolization for intrahepatic cholangiocarcinoma: A multicenter multicompartment dosimetry study.

European journal of nuclear medicine and molecular imaging·2026

Same author

Delayed ultrasound in ectopic pregnancy: clinical selection, time-dependent diagnosis, and the limits of reassurance.

CJEM·2026

Same author

Surgical outcomes and risk factors for complications after tracheal resection in benign tracheal stenosis: A 15-year single-center experience.

Turk gogus kalp damar cerrahisi dergisi·2026

Same author

Tumour deposits in colorectal carcinoma are associated with immune evasion and dose-dependent adverse prognosis beyond nodal status.

British journal of cancer·2026

Same author

Can heat stress affect the psychophysiological responses and locomotor demands of young soccer players during small-sided soccer games?

PloS one·2026

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune-complex

Funda Saglam¹, Ali Celik, Devrim Tayfur

¹Departments of Nephrology, Dokuz Eylul University School of Medicine, Balcova, Turkey. funda.saglam@deu.edu.tr

Nephrology (Carlton, Vic.)

|July 24, 2010

Summary

This summary is machine-generated.

Doxycycline treatment reduced kidney damage and inflammation in a rat model of immune-complex nephritis. This matrix metalloproteinase inhibitor shows potential for treating proliferative glomerulonephritis.

More Related Videos

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Published on: November 23, 2017

Related Experiment Videos

Last Updated: Jun 10, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Published on: November 23, 2017

Area of Science:

Nephrology
Immunology
Pharmacology

Background:

Matrix metalloproteinases (MMP) and their inhibitors (TIMP) play a role in tubulointerstitial fibrosis in progressive glomerulonephritis (GN).
Immune-complex nephritis (ICN) is a form of GN characterized by inflammation and potential fibrosis.

Purpose of the Study:

To evaluate the therapeutic efficacy of doxycycline, an MMP inhibitor, in an experimental rat model of immune-complex nephritis (ICN).

Main Methods:

Immune-complex glomerulonephritis was induced in rats via bovine serum albumin (BSA) administration.
Rats received daily doxycycline (30 mg/kg) or a placebo for 28 days.
Kidney tissue analysis included glomerular morphology, immunoglobulin and C3 deposition, interstitial inflammation, and MMP expression (MMP-9, pro-MMP-2).

Main Results:

Doxycycline treatment significantly reduced glomerular area and cell proliferation compared to controls.
Treated rats exhibited less intense glomerular IgG and C3 deposition.
Glomerular MMP-9 expression and pro-MMP-2 levels were significantly suppressed by doxycycline in ICN rats.

Conclusions:

Doxycycline demonstrated a therapeutic effect in reducing key pathological features of immune-complex nephritis in rats.
Beyond its antibiotic properties, doxycycline may offer a survival benefit in proliferative glomerulonephritis, warranting further investigation.