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Related Experiment Videos

Reconstructionist molecular biology.

M A Savageau1

  • 1Department of Microbiology and Immunology, University of Michigan, Ann Arbor 48109-0620.

The New Biologist
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

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Extending the method of mathematically controlled comparison to include numerical comparisons.

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Comparing systemic properties of ensembles of biological networks by graphical and statistical methods.

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The seventh Bellman Prize.

Mathematical biosciences·1999

A new wave of reductionism in biology is unifying the field through common methods and central themes like signal transmission. This approach tackles biological complexity and organization, paving the way for understanding network evolution.

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Genetics

Background:

  • A "new reductionism" in biology fosters unity, unlike older forms that caused specialization.
  • Common experimental methodologies and key themes like signal transmission and differential gene expression are driving this unification.

Purpose of the Study:

  • To describe complementary developments in molecular biology focusing on complexity and organization.
  • To present a general approach for relating systemic behavior to molecular determinants.

Main Methods:

  • Analysis of simple examples illustrating the complexity-determinant relationship.
  • Outlining a general approach to understanding biological organization.

Main Results:

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  • Demonstrated the difficulty in linking systemic behavior to underlying molecular properties.
  • Presented a framework for addressing biological complexity and organization.

    • Conclusions:

    • Developments in molecular biology are leading to an integrative paradigm.
    • This new paradigm will enable the study of network function, design, and evolution, issues intractable with current models.