Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrafractional stability of MR-guided online adaptive SBRT for prostate cancer.

Radiation oncology (London, England)·2021
Same author

Comparisons of PNEC derivation logic flows under example regulatory schemes and implications for ecoTTC.

Regulatory toxicology and pharmacology : RTP·2021
Same author

SSDs Revisited: Part I-A Framework for Sample Size Guidance on Species Sensitivity Distribution Analysis.

Environmental toxicology and chemistry·2019
Same author

SSDs revisited: part II-practical considerations in the development and use of application factors applied to species sensitivity distributions.

Environmental toxicology and chemistry·2019
Same author

The use of cell culture platforms to identify novel markers of bone and dentin resorption.

Orthodontics & craniofacial research·2017
Same author

Vemurafenib in metastatic melanoma patients with brain metastases: an open-label, single-arm, phase 2, multicentre study.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same journal

PM<sub>2.5</sub> exposure impairs mitochondrial function and myocardial contractility in cardiac organoids via the Sirt3/Mdh2 pathway.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Evaluation of an in-vitro test protocol using a three-dimensional human buccal oral mucosal model to assess the oral medical devices.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Descriptive oxidative and lipid-related fluorescence observations associated with Esketamine treatment in a high-concentration NMDA-exposed HT-22/C8-D1A co-culture model.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Integration of label-free electrochemical sensing, differential privacy deep learning, and blockchain for secure cytotoxicity monitoring.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Pulmonary permeability assessment using two human lung epithelial cell models in air-liquid interface cultures.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

In vivo toxicity of some cyanide-containing compounds in zebrafish (Danio rerio) embryos.

Toxicology in vitro : an international journal published in association with BIBRA·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture
08:32

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Published on: October 20, 2023

Alternatives in cosmetics testing.

N Loprieno1, L H Bruner, G J Carr

  • 1Department of Environmental Sciences, University of Pisa, 56123 Pisa, Italy.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|July 24, 2010
PubMed
Summary
This summary is machine-generated.

This summary covers a roundtable on alternative methods in cosmetic safety assessment. It highlights industry adoption, validation studies, and integrated approaches like quantitative structure-activity relationship (QSAR) analysis.

More Related Videos

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model
10:13

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Published on: August 23, 2015

Related Experiment Videos

Last Updated: Jun 10, 2026

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture
08:32

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Published on: October 20, 2023

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model
10:13

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Published on: August 23, 2015

Area of Science:

  • Toxicology
  • Cosmetic Science
  • Regulatory Affairs

Background:

  • The cosmetic industry is increasingly adopting alternative methods for safety assessment.
  • Regulatory bodies and industry associations are key drivers in this transition.
  • Global harmonization of safety testing is an ongoing challenge.

Purpose of the Study:

  • To summarize discussions on the use of alternative methods in cosmetic safety assessment.
  • To outline the adoption of alternative methods by specific industries and regions.
  • To discuss the impact of data variability and integrated approaches on validation.

Main Methods:

  • The content is based on presentations from the ECVAM Opening Symposium roundtable discussion.
  • It synthesizes information on industry practices, validation studies, and regulatory involvement.
  • Qualitative review of presented strategies and challenges.

Main Results:

  • L'Oréal and the Japanese cosmetic industry are actively using alternative methods.
  • Ongoing validation studies in Japan are contributing to method acceptance.
  • The European Cosmetic, Toiletry and Perfumery Association (COLIPA) plays a role in promoting these methods.

Conclusions:

  • Data variability significantly affects the performance of alternative methods in validation.
  • Integrating quantitative structure-activity relationship (QSAR) analysis with other methods enhances safety assessment.
  • Continued collaboration and research are essential for the advancement and acceptance of alternative methods in cosmetic safety.