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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Published on: May 9, 2025

Amphetamine-group substances and HIV.

Grant Colfax1, Glenn-Milo Santos, Priscilla Chu

  • 1HIV Prevention Section, San Francisco Department of Public Health, San Francisco, CA 94102, USA. grant.colfax@sfdph.org

Lancet (London, England)
|July 24, 2010
PubMed
Summary
This summary is machine-generated.

High-intensity behavioral interventions moderately reduce amphetamine-group substance use. However, evidence is inconclusive on their superiority over minimal interventions for reducing substance use or sexual risk behaviors.

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Area of Science:

  • Public Health
  • Addiction Medicine
  • Behavioral Science

Background:

  • Amphetamine-group substances are globally prevalent, exceeding cocaine and opioid use.
  • Non-injection amphetamine use is linked to increased HIV risk, especially in men who have sex with men.
  • Underlying factors connecting amphetamine use and HIV risk remain poorly understood.

Purpose of the Study:

  • To review published reports on amphetamine-group substances.
  • To conduct a meta-analysis of randomized controlled trials for behavioral interventions targeting amphetamine use.
  • To assess the effectiveness of behavioral interventions in reducing amphetamine use and associated risks.

Main Methods:

  • Systematic review of published literature.
  • Meta-analysis of 13 randomized controlled trials involving 1997 participants.
  • Evaluation of behavioral interventions for amphetamine-group substance use.

Main Results:

  • High-intensity behavioral interventions showed moderate effectiveness in reducing amphetamine-group substance use (effect size 0.28).
  • No conclusive evidence demonstrated that behavioral interventions, as a group, are more effective than passive or minimal treatments.
  • The association between amphetamine use and HIV risk is noted, though not universally consistent across all studies.

Conclusions:

  • While high-intensity interventions show some promise, further research is needed.
  • The search for scalable, sustainable interventions, including pharmacotherapies, for amphetamine-group substance use should be prioritized.
  • More research is required to understand the complex factors driving amphetamine use and HIV risk.