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Updated: Jun 10, 2026

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
Published on: June 10, 2022
Lipophilic phenolic antioxidants: correlation between antioxidant profile, partition coefficients and redox
Fernanda M F Roleira1, Christophe Siquet, Elizabeta Orrù
1CEF/Laboratório de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Portugal. froleira@ff.uc.pt
Abstract:
Lipophilic compounds structurally based on caffeic, hydrocaffeic, ferulic and hydroferulic acids were synthesized. Subsequently, their antioxidant activity was evaluated as well as their partition coefficients and redox potentials. The structure-property-activity relationship (SPAR) results revealed the existence of a clear correlation between the redox potentials and the antioxidant activity. In addition, some compounds showed a proper lipophilicity to cross the blood-brain barrier. Their predicted ADME properties are also in accordance with the general requirements for potential CNS drugs. Accordingly, one can propose these phenolic compounds as potential antioxidants for tackling the oxidative status linked to the neurodegenerative processes.
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