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[Correlation of IL-1beta-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a meta-analysis]
1Department of Cardiology, Xiangya Hospital, and Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha 410008, China.
Insights
Gene variations in Interleukin-1 beta (IL-1beta) and IL-1 receptor antagonist (IL-1RN) VNTR do not appear to increase the risk of developing coronary heart disease (CHD). Further research is needed on their role in disease progression.
Area of Science:
- Genetics
- Cardiology
- Immunology
Objective:
To evaluate the correlation between the gene polymorphism of IL-1beta-511 or IL-1RN VNTR and the risk of coronary heart disease (CHD).
Methods:
The patient-control studies on the association of IL-1=-511 or IL-1RN VNTR gene polymorphism with the risk of CHD were searched according to the inclusion criteria. Heterogeneity tests were conducted for the data from each study before Meta-analysis.
Results:
For the 7 studies addressing the correlation between IL-1beta-511 polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.04 with 95% CI of 0.93-1.18 (Z=0.71, P=0.48). For the 5 studies of the correlation between IL-1RN VNTR polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.01 and the 95% CI was 0.78-1.17 (Z=0.08, P=0.93).
Conclusion:
The gene polymorphism of IL-1beta-511 or IL-1RN VNTR has no correlation to the susceptibility of CHD, but is associated with in the disease development and clinical phenotype.
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