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Related Experiment Video

Updated: Jun 10, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

A novel animal model for hyperdynamic airway collapse.

Hisashi Tsukada¹, Carl R O'Donnell, Robert Garland

¹Caritas Christi Health Care, Boston, MA 02135, USA.

|July 24, 2010

Summary

Researchers developed a sheep model for tracheobronchomalacia (TBM) by surgically inducing airway collapse. This model allows for the evaluation of new diagnostic and treatment strategies for TBM.

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Last Updated: Jun 10, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

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Published on: April 7, 2021

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)

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Published on: September 7, 2016

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Published on: April 5, 2018

Area of Science:

Pulmonary Medicine
Surgical Innovation
Animal Modeling

Background:

Tracheobronchomalacia (TBM) causes significant lung problems.
Lack of a suitable animal model hinders TBM research and treatment development.

Purpose of the Study:

To create a reliable animal model simulating human hyperdynamic airway collapse.
To enable evaluation of novel diagnostic and therapeutic strategies for TBM.

Main Methods:

Surgical induction of tracheomalacia in seven sheep via tracheal cartilage resection.
Assessment of tracheal collapsibility using bronchoscopy and CT imaging.
Measurement of flow limitation and pleural pressure during spontaneous breathing.

Main Results:

The surgical technique reliably induced near-total inspiratory airway collapse in sheep for up to three months.
Flow limitation and significant negative pleural pressure swings were observed during inhalation.
One sheep experienced respiratory failure due to stent migration.

Conclusions:

This surgical technique effectively creates a model of hyperdynamic airway collapse.
The developed model can be utilized for assessing new diagnostic tools and treatments for TBM.