Significant publications on infectious diseases pharmacotherapy in 2009

Hannah R Palmer1, Jessica M Cottreau, Kevin W Garey

  • 1St. Luke's Episcopal Hospital, Houston, TX, USA.

Insights

This review highlights key 2009 publications impacting infectious diseases (ID) pharmacotherapy. Experts identified top articles to help clinicians stay current with essential ID drug therapy advancements.

Area of Science:

  • Pharmacotherapy
  • Infectious Diseases
  • Medical Literature Review

Background:

  • The rapid growth of publications in infectious diseases (ID) pharmacotherapy makes it challenging for professionals to stay updated.
  • Identifying significant contributions to the field is crucial for advancing pharmacy practice.

Purpose of the Study:

  • To summarize significant publications in infectious diseases (ID) pharmacotherapy from 2009.
  • To assist healthcare professionals in staying abreast of critical advancements in ID drug therapy.

Main Methods:

  • A survey was distributed to members of the Society of Infectious Diseases Pharmacists (SIDP).
  • Respondents identified the most impactful articles from a curated list of 2009 publications.
  • Articles were categorized into HIV-related and non-HIV-related groups.

Main Results:

  • 100 out of 531 SIDP members responded to the survey (18.8% response rate).
  • The survey identified the top 10 most significant publications impacting ID pharmacotherapy in 2009 (9 non-HIV, 1 HIV-related).
  • Three of the top non-HIV articles were new or updated ID guidelines.

Conclusions:

  • This review consolidates essential ID pharmacotherapy literature, reducing the burden on practitioners.
  • The identified articles represent critical advancements in infectious diseases drug therapy for 2009.
  • Staying informed on key publications is vital for evidence-based pharmacy practice in ID.
Abstract

Related Concept Videos

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...