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Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling

Saadia Bashir Hassan1, Hala Gali-Muhtasib, Hanna Göransson

  • 1Division of Clinical Pharmacology, Department of Medical Sciences, University Hospital, 751 85 Uppsala, Sweden. sadia.hassan@medsci.uu.se

Anticancer Research
|July 24, 2010
PubMed
Abstract

Insights

Alpha terpineol, found in Salvia libanotica, inhibits tumor cell growth by blocking the NF-kappaB pathway. This natural compound shows promise as an anti-cancer agent, particularly against small cell lung carcinoma.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Oncology

Background:

  • Alpha terpineol is a bioactive compound derived from Salvia libanotica essential oil.
  • This compound has demonstrated potential anti-tumorigenic properties.

Purpose of the Study:

  • To evaluate the anti-cancer effects of alpha terpineol.
  • To elucidate the molecular mechanisms underlying its anti-tumor activity.

Main Methods:

  • In vitro cytotoxicity assays on various tumor cell lines.
  • Mechanistic studies using cell line panels and gene expression analysis (Connectivity Map).
  • NF-kappaB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) pathway assays to assess inhibition of translocation and activity.

Main Results:

  • Small cell lung carcinoma cell lines were most sensitive to alpha terpineol.
  • Alpha terpineol was identified as an inhibitor of the NF-kappaB pathway.
  • Dose-dependent inhibition of NF-kappaB activity and down-regulation of NF-kappaB-related genes (e.g., IL-1 beta, IL1R1) were observed.

Conclusions:

  • Alpha terpineol exhibits anti-tumor activity.
  • The mechanism involves the inhibition of the NF-kappaB signaling pathway.
  • Alpha terpineol represents a potential therapeutic agent for cancer treatment.

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