Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the antioxidant and anticancer potential of local mediterranean olive and fig extracts against breast cancer.

BMC complementary medicine and therapies·2026
Same author

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells <i>ex vivo</i> and in an <i>in vivo</i> mouse model.

Oncology reports·2025
Same author

Correction: Al Bitar et al. Thymoquinone Radiosensitizes Human Colorectal Cancer Cells in 2D and 3D Culture Models. <i>Cancers</i> 2022, <i>14</i>, 1363.

Cancers·2025
Same author

Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients.

HemaSphere·2025
Same author

Omics technologies as powerful approaches to unravel colorectal cancer complexity and improve its management.

Molecules and cells·2025
Same author

Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models.

SLAS technology·2024

Related Experiment Video

Updated: Jun 10, 2026

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling.

Saadia Bashir Hassan1, Hala Gali-Muhtasib, Hanna Göransson

  • 1Division of Clinical Pharmacology, Department of Medical Sciences, University Hospital, 751 85 Uppsala, Sweden. sadia.hassan@medsci.uu.se

Anticancer Research
|July 24, 2010
PubMed
Summary

Alpha terpineol, found in Salvia libanotica, inhibits tumor cell growth by blocking the NF-kappaB pathway. This natural compound shows promise as an anti-cancer agent, particularly against small cell lung carcinoma.

More Related Videos

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

Related Experiment Videos

Last Updated: Jun 10, 2026

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Oncology

Background:

  • Alpha terpineol is a bioactive compound derived from Salvia libanotica essential oil.
  • This compound has demonstrated potential anti-tumorigenic properties.

Purpose of the Study:

  • To evaluate the anti-cancer effects of alpha terpineol.
  • To elucidate the molecular mechanisms underlying its anti-tumor activity.

Main Methods:

  • In vitro cytotoxicity assays on various tumor cell lines.
  • Mechanistic studies using cell line panels and gene expression analysis (Connectivity Map).
  • NF-kappaB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) pathway assays to assess inhibition of translocation and activity.

Main Results:

  • Small cell lung carcinoma cell lines were most sensitive to alpha terpineol.
  • Alpha terpineol was identified as an inhibitor of the NF-kappaB pathway.
  • Dose-dependent inhibition of NF-kappaB activity and down-regulation of NF-kappaB-related genes (e.g., IL-1 beta, IL1R1) were observed.

Conclusions:

  • Alpha terpineol exhibits anti-tumor activity.
  • The mechanism involves the inhibition of the NF-kappaB signaling pathway.
  • Alpha terpineol represents a potential therapeutic agent for cancer treatment.