Related Experiment Video
Updated: Jun 10, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Vulvar cancer: prognostic factors.
Maria Ornella Nicoletto1, Anna Parenti, Paola Del Bianco
1Medical Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata, 64, 35128 Padova, Italy.
Anticancer Research
|July 24, 2010
Summary
Surgery, stage, and stromal invasion over 9 mm are key predictors of relapse-free survival in vulvar squamous cell carcinoma. Lower histological grades also indicate better disease-free survival for these patients.
Area of Science:
- Gynecologic Oncology
- Surgical Pathology
Background:
- Vulvar squamous cell carcinoma (VSCC) is a rare malignancy.
- Identifying prognostic factors is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate prognostic factors influencing relapse-free survival in patients with VSCC.
- To determine the impact of surgical treatment, tumor stage, and histopathological features on patient outcomes.
Main Methods:
- Retrospective analysis of 47 VSCC patients treated at the University of Padua.
- Univariate and multivariate analyses were performed to assess prognostic variables.
- Key factors analyzed included histological grade, disease stage, surgical approach, and stromal invasion depth.
Main Results:
- Histological grade, disease stage, and type of surgery were significantly associated with relapse-free survival in univariate analysis.
- Local recurrence was observed in 55.3% of patients.
- Stromal invasion exceeding 9 mm was a significant predictor of relapse (p=0.0066).
Conclusions:
- Multivariate analysis identified surgery, stage, and stromal invasion >9 mm as dominant predictors of relapse-free survival.
- Histological grades 1 and 2 were associated with improved disease-free survival (p=0.0012).
- These findings emphasize the importance of surgical technique and detailed pathological assessment in managing VSCC.
Related Concept Videos
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...