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Related Concept Videos

Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild...
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild...
Enzymes02:34

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Catalysis01:27

Catalysis

Catalysis influences the rate of chemical reactions by providing an alternative reaction pathway with lower activation energy. A catalyst speeds up a reaction, but it is not consumed during the process. The fundamental principle of catalysis is the ability of a catalyst to alter the reaction mechanism, often introducing a more efficient pathway than the uncatalyzed process.In a catalyzed reaction, the catalyst participates directly in the reaction mechanism. It interacts with reactants to form...
Catalysis02:50

Catalysis

The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
Catalytically Perfect Enzymes01:07

Catalytically Perfect Enzymes

The theory of catalytically perfect enzymes was first proposed by W.J. Albery and J. R. Knowles in 1976. These enzymes catalyze biochemical reactions at high-speed. Their catalytic efficiency values range from 108-109 M-1s-1. These enzymes are also called 'diffusion-controlled' as the only rate-limiting step in the catalysis is that of the substrate diffusion into the active site. Examples include triose phosphate isomerase, fumarase, and superoxide dismutase.

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Related Experiment Video

Updated: Jun 10, 2026

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
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Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

Supramolecular catalysis beyond enzyme mimics.

Jurjen Meeuwissen1, Joost N H Reek

  • 1Homogeneous and Supramolecular Catalysis, Van 't Hoff Institute for Molecular Sciences, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands.

Nature Chemistry
|July 24, 2010
PubMed
Summary

Supramolecular catalysis uses multiple weak interactions to assemble catalysts. This approach expands beyond enzymes to transition metal and organocatalysis, enabling rapid discovery of efficient catalysts for industrial applications.

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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

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Last Updated: Jun 10, 2026

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
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Published on: June 24, 2022

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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Area of Science:

  • Supramolecular Chemistry
  • Catalysis
  • Chemical Engineering

Background:

  • Supramolecular catalysis traditionally focused on enzyme-inspired designs.
  • Previous methods concentrated on mimicking enzyme active sites and reactions.

Purpose of the Study:

  • To explore supramolecular assembly in transition metal catalysis and small-molecule organocatalysis.
  • To highlight the modularity and efficiency of multicomponent self-assembled catalysts.

Main Methods:

  • Application of supramolecular assembly principles.
  • Development of modular, self-assembled multicomponent catalysts.
  • Evaluation of catalysts for industrially relevant reactions.

Main Results:

  • Demonstrated successful application of supramolecular assembly to non-enzymatic catalysis.
  • Showcased rapid access to a large library of catalysts from a small component pool.
  • Highlighted the ability to tailor catalyst-substrate interactions for selectivity.

Conclusions:

  • Supramolecular catalysis offers a versatile platform beyond enzyme mimicry.
  • Modular catalyst design accelerates the discovery of catalysts for industrial processes.
  • Precise control over catalyst-substrate interactions enhances reaction pathways and selectivity.