Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical Evaluation of a Novel Polymer-free Everolimus-eluting Stent in a Mid-term Porcine Coronary Restenosis Model.

Journal of Korean medical science·2021
Same author

Aberrant Migration of Thrombi Originating from Ruptured Plaque Along the "Spinning Roller Coaster Track" after Aspiration Thrombectomy.

Chonnam medical journal·2021
Same author

Minimally Invasive Transcatheter Aortic Valve Replacement and Sequential Repair of Abdominal Aortic Aneurysm in an Octogenarian.

Chonnam medical journal·2021
Same author

Transcatheter aortic valve replacement via a transsubclavian approach in a patient with severe aortic stenosis who had previously undergone kidney transplantation: A case report.

Medicine·2021
Same author

Paired comparisons of mutational profiles before and after brachytherapy in asian uveal melanoma patients.

Scientific reports·2021
Same author

Comparison of long-term clinical outcomes among zotarolimus-, everolimus-, and biolimus-eluting stents in acute myocardial infarction patients with renal impairment.

Cardiology journal·2021

Related Experiment Video

Updated: Jun 10, 2026

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress
05:22

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress

Published on: July 29, 2022

Identifying Genomic Regulators of Set-Wise Co-Expression.

Jung Hoon Woo1, Tian Zheng, Ju Han Kim

  • 1Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul 110-799, Korea.

Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering
|July 24, 2010
PubMed
Summary

This study introduces a new method to find genetic regulators controlling groups of co-expressed genes. This approach reveals the heritability of mRNA co-expression, offering insights into gene regulation.

More Related Videos

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

Related Experiment Videos

Last Updated: Jun 10, 2026

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress
05:22

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress

Published on: July 29, 2022

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

Area of Science:

  • Genetics
  • Systems Biology
  • Bioinformatics

Background:

  • Genetical genomics identifies genetic regulators of individual gene expression variation.
  • Coordinated gene activity within molecular pathways is also regulated, but these mechanisms are complex.
  • Understanding the regulation of set-wise gene co-expression is crucial for systems biology.

Purpose of the Study:

  • To develop and apply a novel method for identifying genomic regulators of set-wise co-expression.
  • To investigate the genetic basis of coordinated gene activity in biological pathways.
  • To provide evidence for the heritability of mRNA co-expression.

Main Methods:

  • Utilized genetical genomics data to search for genomic regulators of set-wise co-expression.
  • Applied a quantitative trait mapping approach to identify regulatory loci.
  • Analyzed 233 biological pathways using a BXD RI data set.
  • Controlled for false discovery rate to ensure significance.

Main Results:

  • Identified significant regulatory loci for 15 out of 233 biological pathways.
  • Demonstrated that genetic regulators can influence the co-expression of sets of genes.
  • Provided evidence supporting the heritability of mRNA co-expression patterns.

Conclusions:

  • A new method effectively identifies genomic regulators of gene set co-expression using existing genetical genomics data.
  • The study confirms that mRNA co-expression is a heritable trait.
  • Defining novel phenotypes from genetical genomics data yields insights into co-expression regulation.