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Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

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Published on: October 12, 2012

Coma Blisters.

Joana Rocha1, Teresa Pereira, Filipa Ventura

  • 1Department of Dermatology, Hospital de São Marcos, Braga, Portugal.

Case Reports in Dermatology
|July 24, 2010
PubMed
Summary
This summary is machine-generated.

Coma blisters, skin lesions linked to neurological conditions, can occur beyond drug overdoses. This case highlights their appearance in a patient with meningoencephalitis, resolving without specific treatment.

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Area of Science:

  • Neurology
  • Dermatology
  • Internal Medicine

Background:

  • Coma blisters are skin lesions associated with neurological diseases.
  • While commonly linked to barbiturate overdose, they can arise from other causes of coma.
  • These blisters typically manifest 48-72 hours after the onset of unconsciousness.

Purpose of the Study:

  • To report a case of coma blisters in a patient with presumed bacterial meningoencephalitis.
  • To describe the clinical presentation, diagnostic findings, and outcome of this rare condition.

Main Methods:

  • Case report of a 29-year-old male with confusion and progressive loss of consciousness.
  • Clinical evaluation, laboratory tests (serum glucose, liver and kidney function), and toxicological screening.
  • Skin biopsy to characterize the blister morphology.

Main Results:

  • The patient developed coma with altered hepatic and renal function, normal toxicology.
  • Multiple tense hemorrhagic blisters appeared on extremities two days after coma onset.
  • Skin biopsy showed intraepidermal blisters with epidermal necrosis; patient recovered fully within two weeks.

Conclusions:

  • Coma blisters can occur in non-overdose related coma, such as meningoencephalitis.
  • The lesions resolved spontaneously without specific dermatological treatment.
  • This case underscores the importance of considering diverse etiologies for coma blisters.