Randomized trial of oral versus sublingual misoprostol 24 h after mifepristone for medical abortion
Related Experiment Video
Updated: Jun 10, 2026
Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
Published on: February 3, 2026
Krishna Dahiya1, Sonika Mann, Smiti Nanda
1Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, 124001, Haryana, India. krishnadahiya@rediffmail.com
Objectives:
To assess the efficacy, side effects, and acceptability of medical abortion using oral mifepristone (200 mg) followed 24 h later by oral or sublingual misoprostol (400 μg).
Materials And Methods:
A total of 93 women with pregnancies up to 56 days of gestational age were assigned to two groups according to the different misoprostol regimen (group I 400 μg orally and group II 400 μg sublingually). The principle outcome measure was complete abortion defined as a complete expulsion of intrauterine contents without a need for surgical intervention 7 days after the procedure.
Results:
Successful abortion occurred in 87.5% of patients in group 1 and 95.5% patients in group 2 (p = 0.166, 95% CI -0.194, 0.033). The patient acceptability and satisfaction rates were similar in both the groups.
Conclusion:
It is concluded that 400 μg of sublingual misoprostol is as effective as oral misoprostol 24 h after mifepristone for medical abortion of ≤ 56 days.
