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Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis
T Matthew Eison1, Bettina H Ault, Deborah P Jones
1Division of Pediatric Nephrology, Department of Pediatrics, University of Tennessee Health Science Center, and Children's Foundation Research Center at Le Bonheur Children's Medical Center, 50 North Dunlap, Memphis, TN 38103, USA.
Pediatric Nephrology (Berlin, Germany)
|July 24, 2010
Summary
Post-streptococcal acute glomerulonephritis (PSAGN) affects children worldwide, often causing acute kidney injury. This review details PSAGN
Area of Science:
- Pediatric Nephrology
- Immunology
- Infectious Diseases
Background:
- Post-streptococcal acute glomerulonephritis (PSAGN) is a significant cause of acute kidney injury in children.
- While most cases resolve favorably, PSAGN contributes to pediatric hospitalizations globally.
- Understanding PSAGN is crucial for pediatric nephrology practice.
Purpose of the Study:
- To review the clinical presentation of PSAGN, including typical and atypical features.
- To analyze epidemiological shifts in PSAGN over the last five decades.
- To examine the pathogenesis of PSAGN, focusing on identifying the nephritogenic antigen.
Main Methods:
- Literature review of clinical studies on PSAGN.
- Analysis of epidemiological data spanning 50 years.
- Exploration of research on PSAGN pathogenesis and antigen identification.
Main Results:
- PSAGN presents with diverse clinical manifestations.
- Epidemiological patterns of PSAGN have evolved.
- Research continues to investigate the specific antigen triggering PSAGN.
Conclusions:
- PSAGN remains a relevant pediatric renal condition with changing epidemiology.
- Further research into the nephritogenic antigen is essential for understanding PSAGN.
- Comprehensive review aids in managing and understanding this pediatric kidney disease.
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