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Updated: Jun 10, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application
Kiyoshi Mori1, Masashi Mukoyama, Kazuwa Nakao
1Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan. keyem@kuhp.kyoto-u.ac.jp
Abstract:
In this review, isolation and characterization of several kidney-derived molecules are described, namely carbonic anhydrase XIV, cysteine-rich protein 61, and kidney-liver-specific immunoglobulin-like protein. Features of neutrophil gelatinase-associated lipocalin (LCN2 or human neutrophil lipocalin) as a kidney differentiation inducer and renal injury biomarker and also as an iron-carrier protein are also summarized. Furthermore, the concepts of forest fire theory and the biology of siderophore-binding proteins are discussed.
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