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Related Experiment Videos

The longstanding MS lesion. A quantitative MRI and electron microscopic study.

D Barnes1, P M Munro, B D Youl

  • 1Institute of Neurology, National Hospital, Queen Square, London, UK.

Brain : a Journal of Neurology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

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Chronic multiple sclerosis (MS) lesions show significant tissue damage and extracellular space expansion, suggesting progressive axonal loss. This damage may correlate with long-term disease progression.

Area of Science:

  • Neuroscience
  • Pathology
  • Radiology

Background:

  • The sequence of events leading to irreversible tissue damage in multiple sclerosis (MS) remains unclear.
  • Understanding chronic MS lesions is crucial for managing disease progression.

Purpose of the Study:

  • To investigate the pathological characteristics of longstanding MS lesions.
  • To assess blood-brain barrier function within chronic MS lesions using advanced MRI techniques.

Main Methods:

  • Quantitative and Gadolinium-DTPA enhanced MRI techniques were employed.
  • Ultrastructural analysis of postmortem MS lesions was correlated with MRI findings.

Main Results:

  • Chronic MS lesions exhibit significant heterogeneity, with most showing expanded extracellular space (up to 87%).

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  • This expansion is likely due to varying degrees of axonal loss.
  • Blood-brain barrier damage was observed in only 17% of lesions and was less severe than in acute lesions.

    • Conclusions:

    • Progressive axonal loss occurs as MS lesions age.
    • This age-related axonal loss may be linked to the clinical progression of multiple sclerosis.