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Updated: Jun 10, 2026
04:04
Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity
Published on: January 20, 2023
Functional impact of transposable elements using bioinformatic analysis and a comparative genomic approach
Dae-Soo Kim1, Jae-Won Huh, Young-Hyun Kim
1National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang 363-883, Korea.
Molecules and Cells
|July 24, 2010
Summary
Transposable elements (TEs) contribute to dual coding events, generating protein diversity in humans but not mice. This study quanties TE-derived dual coding genes across species, revealing their significant role in human genome evolution.
Area of Science:
- Genomics
- Molecular Biology
- Evolutionary Biology
Background:
- Dual coding events, arising from alternative splicing, generate protein diversity.
- Transposable elements (TEs) can be integrated into mature mRNAs through exonization.
- The role of TE-derived dual coding events in genome evolution is not fully understood.
Purpose of the Study:
- To investigate the prevalence of TE-derived dual coding genes in human, chimpanzee, and mouse genomes.
- To analyze the impact of TE-derived dual coding events on protein functional domains.
- To compare TE-derived dual coding events across these species.
Main Methods:
- Bioinformatic analysis of human, chimpanzee, and mouse genomes.
- Identification and quantification of TE-derived dual coding events.
- Comparative analysis of orthologous genes.
Main Results:
- 309 human genes exhibited TE fusion exons in dual coding regions.
- 129 human genes showed functional protein domain alterations due to TE-derived dual coding.
- 70 chimpanzee orthologs had TE-derived dual coding events, while mouse orthologs did not.
Conclusions:
- TE-derived dual coding events are a significant source of functional diversity in human genes.
- These events are prevalent in humans and chimpanzees but absent in mice.
- The findings provide a list of TE-derived dual coding genes for further experimental investigation.
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