Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The transcription factor Jun is necessary for optic nerve regeneration in larval zebrafish.

PloS one·2025
Same author

Development and Validation of a Proximity Labeling Fusion Protein Construct to Identify the Protein-Protein Interactions of Transcription Factors.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Mass spectrometry dataset of LC-MS lipidomics analysis of <i>Xenopus laevis</i> optic nerve.

Data in brief·2023
Same author

Profiling Dynamic Changes in DNA Accessibility During Axon Regeneration After Optic Nerve Crush in Adult Zebrafish.

Methods in molecular biology (Clifton, N.J.)·2023
Same author

Cellular reprogramming for successful CNS axon regeneration is driven by a temporally changing cast of transcription factors.

Scientific reports·2019
Same author

Regeneration Rosetta: An Interactive Web Application To Explore Regeneration-Associated Gene Expression and Chromatin Accessibility.

G3 (Bethesda, Md.)·2019
Same journal

Multi-stage transcriptome analysis reveals genetic orchestration of rat testis development.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Three-dimensional observation of the muscle-tendon integration process in mouse embryos.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH-1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode-derived cells in the brain.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Prenatal sexual dimorphism in human pelvic tilt at the onset of fetal ossification.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Meet the editorial team. An interview with Ralph Marcucio, Assistant Editor, University of California San Francisco, United States.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Editorial highlights.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Cabin1 expression suggests roles in neuronal development.

Dena R Hammond1, Ava J Udvadia

  • 1Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|July 24, 2010
PubMed
Summary
This summary is machine-generated.

Cabin1 is a gene crucial for nervous system development. This study shows Cabin1 is expressed in the developing brain, potentially regulating MEF2 and calcineurin activity in neuronal differentiation.

More Related Videos

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

Related Experiment Videos

Last Updated: Jun 10, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Nervous system assembly requires precise gene expression regulation.
  • Cabin1, an essential mouse gene, is found in the developing zebrafish central nervous system (CNS).
  • Cabin1's role in the CNS is unknown, though it represses MEF2 and calcineurin in the immune system.

Purpose of the Study:

  • To investigate the function of Cabin1 in the developing CNS.
  • To determine the temporal and spatial expression of Cabin1 mRNA during CNS development.

Main Methods:

  • Cabin1 was identified from a gene library enriched in developing neurons.
  • Cabin1 mRNA expression was analyzed during zebrafish CNS development.

Main Results:

  • Cabin1 mRNA is expressed in the developing brain during neuronal differentiation.
  • Cabin1 expression overlaps with MEF2 and/or calcineurin in specific CNS regions.

Conclusions:

  • Cabin1 is expressed in the developing nervous system.
  • Cabin1 may regulate MEF2 and calcineurin activity, influencing neuronal differentiation and synaptic refinement.