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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:

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Correction to: Mitochondrial Transfer from Mesenchymal Stem Cells to Macrophages Restricts Inflammation and Alleviates Kidney Injury in Diabetic Nephropathy Mice via PGC-1α Activation.

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Updated: Jun 10, 2026

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
07:39

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

Published on: April 13, 2021

Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram?

Oren Pleniceanu1, Orit Harari-Steinberg, Benjamin Dekel

  • 1Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel.

Stem Cells (Dayton, Ohio)
|July 24, 2010
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for chronic kidney disease (CKD) but may not be effective for end-stage renal disease (ESRD). Research is exploring kidney stem cells for regenerative medicine due to donor organ shortages.

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Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells
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Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells

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Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
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Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

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Last Updated: Jun 10, 2026

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Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
08:06

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

Published on: July 2, 2020

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • End-stage renal disease (ESRD) is a growing health concern, characterized by kidney failure.
  • Chronic kidney disease (CKD) and ESRD prevalence is increasing due to aging populations and comorbidities like diabetes and hypertension.
  • Current treatments for ESRD, such as dialysis and transplantation, face limitations and shortages.

Purpose of the Study:

  • To explore the potential of stem and progenitor cells for therapeutic applications in kidney diseases.
  • To address the demand for kidney progenitors for cell therapy, tissue engineering, and regenerative medicine.
  • To investigate alternative cell sources and strategies for kidney repair, given the limitations of current therapies.

Main Methods:

  • Reviewing the potential of multipotent stem/progenitor populations for therapeutic applications.
  • Evaluating the feasibility of cell-based therapies for CKD and ESRD.
  • Examining extrarenal stem cell sources and pluripotent cells for kidney regeneration.

Main Results:

  • Stem/progenitor cells are crucial for understanding tissue homeostasis and developmental processes.
  • Cell therapy may be beneficial for earlier stages of CKD but less effective for advanced, fibrotic ESRD.
  • Blood and bone marrow stem cells lack nephrogenic potential, necessitating research into alternative kidney stem cell sources.

Conclusions:

  • Cell-based therapies offer a potential alternative for kidney diseases, particularly in earlier CKD stages.
  • The scarcity of donor organs highlights the need for innovative approaches like stem cell therapy.
  • Further research into pluripotent cells, fetal kidney progenitors, or reprogrammed adult kidney cells is essential for advancing kidney regenerative medicine.