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A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms
Published on: December 19, 2025
Atypical presentation of leptospirosis
Prasita Pravin Kshirsagar1, Amey Dilip Sonavane, Aditi Chetan Doshi
1Rajiv Gandhi Medical College and Chattrapati Shivaji Maharaj Hospital, Thane.
The Journal of the Association of Physicians of India
|July 27, 2010
Abstract:
Leptospirosis, a disease of protean manifestations occurs sporadically throughout the year with a peak seasonal incidence during the rainy season. We hereby present a case that had clinical features of nephrotic syndrome with massive proteinuria. Leptospirosis was detected on ELISA testing. Patient was cured with antibiotics and diuretics.
Insights
Leptospirosis can cause nephrotic syndrome with significant proteinuria. Early detection via ELISA and treatment with antibiotics and diuretics led to a full recovery in this case.
Area of Science:
- Nephrology
- Infectious Diseases
Background:
- Leptospirosis is a zoonotic infection with diverse clinical presentations.
- It often presents with seasonal peaks, particularly during rainy periods.
- Nephrotic syndrome is a kidney disorder characterized by massive proteinuria.
Observation:
- A case presented with clinical manifestations mimicking nephrotic syndrome.
- The patient exhibited massive proteinuria, a key indicator of nephrotic syndrome.
Findings:
- Enzyme-Linked Immunosorbent Assay (ELISA) testing confirmed leptospirosis.
- The patient's condition improved significantly following antibiotic therapy.
- Diuretics were also administered as part of the treatment regimen.
Implications:
- This case highlights leptospirosis as a potential cause of nephrotic syndrome.
- Prompt diagnosis and appropriate treatment are crucial for favorable outcomes.
- It underscores the importance of considering infectious etiologies in nephrotic presentations.
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