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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.

Mohammad Hassan Javanbakht1, Seyed Ali Keshavarz, Mahmoud Djalali

  • 1Department of Nutrition and Biochemistry, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

The Journal of Dermatological Treatment
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Vitamins D and E supplementation significantly improved atopic dermatitis symptoms. Combined vitamin D and E treatment showed the greatest reduction in SCORing Atopic Dermatitis (SCORAD) scores.

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Area of Science:

  • Dermatology
  • Nutritional Science
  • Clinical Research

Background:

  • Atopic dermatitis is a chronic inflammatory skin condition characterized by intense itching.
  • Understanding the role of micronutrients in managing atopic dermatitis is crucial for effective treatment strategies.

Purpose of the Study:

  • To evaluate the impact of vitamin D and vitamin E supplementation on the clinical presentation of atopic dermatitis.
  • To assess the efficacy of individual and combined vitamin D and E treatments.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 45 patients with atopic dermatitis.
  • Participants were assigned to receive placebos, vitamin D3, vitamin E, or a combination for 60 days.
  • Clinical improvement was measured using the SCORing Atopic Dermatitis (SCORAD) index, with serum and plasma levels monitored.

Main Results:

  • All treatment groups (vitamin D alone, vitamin E alone, and combined) showed significant reductions in SCORAD scores.
  • The combined vitamin D and E group exhibited the most substantial improvement (64.3% reduction).
  • Higher plasma levels of alpha-tocopherol (vitamin E) correlated with decreased SCORAD scores and disease severity.

Conclusions:

  • Vitamin D and vitamin E demonstrate beneficial effects in managing atopic dermatitis.
  • Supplementation with vitamins D and E, particularly in combination, can effectively improve clinical manifestations of atopic dermatitis.