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[Clinical analysis of 13 cases with growth hormone deficiency combined with pituitary stalk interruption]
Gao-liang Wang1, Jun-fen Fu, Chun-lin Wang
1Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
Objective:
To analyze the clinical characteristics of the patients with pituitary stalk interruption syndrome (PSIS), and to achieve better comprehension of this disease.
Method:
Data of 13 patients with PSIS were retrospectively analyzed for the clinical, laboratory and imaging features.
Result:
All the 13 patients (9 male, 4 female) had the chief complaint of growth retardation, 81.5 - 135.0 cm in body height, which were minus two standard deviations below the average of the normal children of same age and same sex. GH stimulated peak levels were all below 5 microg/L; Among them, one was accompanied by delayed sexual development, one by central diabetes insipidus, one was complicated with central hypothyroidism and one was accompanied by central adrenocortical hypofunction.
Conclusion:
The most remarkable clinical manifestations of patients with PSIS were growth retardation, partial or complete adenohypophyseal dysfunction. MRI revealed absence of pituitary stalk or anterior pituitary hypoplasia with ectopic posterior pituitary gland.
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