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Updated: Jun 10, 2026
Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
[Clinical analysis of ocular adnexal MALT lymphoma]
Wei-wei Xu1, Mao-nian Zhang, Rui-li Wei
1Department of Ophthalmology, General Hospital of PLA, Beijing 100853, China.
Objective:
To study the clinical characteristic features and the treatment of ocular adnexal lymphoma.
Methods:
Between 1996 to 2008, the clinical and imaging features, histopathological and immunohistochemical aspects, prognosis and results of treatments in 32 patients with ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma were retrospectively analyzed.
Results:
This group included 22 males and 10 females. The ages ranged from 23 to 74 years and the average age was 64.1 years. Number of tumors located in the conjunctiva, the orbit and the lacrimal apparatus was 18/32 (56.3%); 9/32 (28.1%) and 5/32 (15.6%), respectively. B ultrasound examination showed hyperechoic masses (28.1%, 9/32), and the echo was not uniformed (84.4%, 27/32). CT examination showed a medium (43.8 +/- 10.7) HU and uniform density (84.6%, 22/26). The signal patterns in MRI tended to be isointense in T1-, T2-weighted imaging (66.67%, 6/9; 88.89%, 8/9). After image examination, all of the 32 cases underwent surgical resection combined with radiotherapy. These cases were followed up from 1 to 12 years. The relapse rate was 12.5%.
Conclusions:
Image examination is useful for the diagnosis of ocular adnexal lymphoma. Pathologic and immunohistochemical examinations can confirm the diagnosis of ocular adnexal lymphoma. MALT lymphoma has a good prognosis after surgical resection combined with radiotherapy.