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Published on: June 3, 2018
[Impact of growth-factor hormone control on the outcome of acromegalic cardiomyopathy]
Qiu-fang She1, Rong Bai, Qiang Zhou
1Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Insights
Controlling growth hormone levels below 5 microg/L significantly improves outcomes for patients with acromegalic cardiomyopathy. Achieving this control is critical for favorable results in acromegaly patients with heart conditions.
Area of Science:
- Endocrinology
- Cardiology
- Internal Medicine
Background:
- Acromegalic cardiomyopathy is a serious complication of acromegaly.
- Growth hormone excess can lead to significant cardiac dysfunction.
Objective:
To observe the impact of growth-factor hormone control on the outcome of acromegalic cardiomyopathy by reviewing cases from our own center and from literatures.
Methods:
Two cases of acromegalic cardiomyopathy from Tongji hospital and 29 acromegalic cardiomyopathy cases with fully accessible data retrieved from PubMed and CNKI websites were included in present study for analysis. They were divided into "Controlled (< 5 microg/L)" or "Uncontrolled" group according to the serum level of growth factor hormone after treatments. Outcome of patients was evaluated by symptom, NYHA class, LV size and function status.
Results:
Incidence of patients with improved symptoms and cardiac performance was significantly higher in "Controlled" group (18/19) compared to those in "Uncontrolled" group (0/12; P < 0.01, chi(2) = 27.1). Post-treatment growth-factor hormone level < 5 microg/L is significantly associated with a satisfactory outcome of acromegalic cardiomyopathy (r = 0.935, P < 0.01).
Conclusions:
Control of serum growth-factor concentration to a value < 5 microg/L is critical and associated with a favorable outcome for patients with acromegalic cardiomyopathy.
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