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Related Concept Videos

What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?01:04

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?01:04

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

Session 2: cell cycle and cell death.

A Forsby1

  • 1Department of Neurochemistry and Neurotoxicology, Stockholm University, S-106 91 Stockholm, Sweden.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

This symposium explored how toxicants affect gene expression and cell signaling, focusing on cell cycle regulation, apoptosis, and neurodegeneration. Key research areas included p53, calcium signaling, and prion diseases.

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Published on: September 1, 2019

Area of Science:

  • Molecular Biology
  • Toxicology
  • Cell Biology
  • Neuroscience

Background:

  • The 5th CFN symposium in Stockholm (1997) featured a session on "Cell cycle and cell death."
  • This session focused on the effects of toxicants on gene expression and intracellular signaling pathways.

Purpose of the Study:

  • To present and discuss current research on the regulation of the cell cycle and cell death mechanisms.
  • To explore the impact of toxicants on cellular processes, including gene regulation and signaling.
  • To foster scientific exchange on topics ranging from cancer and neurodegeneration to prion diseases.

Main Methods:

  • Invited talks by leading scientists covering specific aspects of cell cycle control, apoptosis, and neurotoxicity.
  • Presentation of 12 short communications from a poster session.
  • Research encompassed methodological development, studies on xenobiotic effects on cellular functions, and gene regulation.

Main Results:

  • Discussions covered the role of p53 in cell cycle arrest and apoptosis.
  • Research highlighted the involvement of calcium signaling and protease activation in apoptosis.
  • Signaling alterations and apoptosis in neurodegenerative conditions were examined, alongside neurotoxicity and neuroinvasion of prions.

Conclusions:

  • The symposium underscored the complex interplay between toxicants, gene expression, intracellular signaling, and cellular fate.
  • Understanding these mechanisms is crucial for addressing diseases like cancer and neurodegeneration.
  • Further research into xenobiotic effects and cellular responses is warranted.