Related Experiment Videos
Studies on psoriatic osteopathy
G Hein1, K Abendroth, A Müller
1Department of Internal Medicine, Friedrich Schiller University, Jena, Germany.
Clinical Rheumatology
|March 1, 1991
Summary
This study reveals a generalized "latent" osteopathy in patients with psoriasis (Ps) and psoriatic arthritis (PA), characterized by increased bone turnover. Latent vitamin D deficiency or resistance is implicated as a shared factor.
Area of Science:
- Dermatology
- Rheumatology
- Endocrinology
- Bone Metabolism
Background:
- Psoriasis (Ps) and psoriatic arthritis (PA) are inflammatory conditions.
- A generalized osteopathy in psoriatic disease has been postulated but not fully demonstrated.
- Understanding bone metabolism alterations is crucial for managing these conditions.
Purpose of the Study:
- To investigate evidence of generalized osteopathy in patients with Ps and PA.
- To evaluate bone turnover markers and bone histology in psoriatic disease.
- To identify potential pathogenetic links between skin and bone manifestations.
Main Methods:
- Serum calcium and alkaline phosphatase levels were measured.
- Urinary hydroxyproline excretion was assessed.
- Bone biopsies from patients with PA and Ps underwent histological and morphometric analysis.
Main Results:
- Evidence of generalized "latent" osteopathy was found in both Ps and PA patients.
- This osteopathy is characterized by an elevated bone turnover rate with preserved bone volume (high turnover remodeling).
- No significant difference in bone turnover was observed between Ps and PA groups.
Conclusions:
- The findings support the existence of a generalized "latent" osteopathy in psoriatic disease.
- Latent vitamin D deficiency and/or vitamin D hormone resistance are discussed as potential shared pathogenetic factors.
- This highlights a potential link between dermatosis and bone alterations in psoriatic patients.