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Studies on psoriatic osteopathy.

G Hein1, K Abendroth, A Müller

  • 1Department of Internal Medicine, Friedrich Schiller University, Jena, Germany.

Clinical Rheumatology
|March 1, 1991
PubMed
Summary
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This study reveals a generalized "latent" osteopathy in patients with psoriasis (Ps) and psoriatic arthritis (PA), characterized by increased bone turnover. Latent vitamin D deficiency or resistance is implicated as a shared factor.

Area of Science:

  • Dermatology
  • Rheumatology
  • Endocrinology
  • Bone Metabolism

Background:

  • Psoriasis (Ps) and psoriatic arthritis (PA) are inflammatory conditions.
  • A generalized osteopathy in psoriatic disease has been postulated but not fully demonstrated.
  • Understanding bone metabolism alterations is crucial for managing these conditions.

Purpose of the Study:

  • To investigate evidence of generalized osteopathy in patients with Ps and PA.
  • To evaluate bone turnover markers and bone histology in psoriatic disease.
  • To identify potential pathogenetic links between skin and bone manifestations.

Main Methods:

  • Serum calcium and alkaline phosphatase levels were measured.
  • Urinary hydroxyproline excretion was assessed.

Related Experiment Videos

  • Bone biopsies from patients with PA and Ps underwent histological and morphometric analysis.

    • Main Results:

    • Evidence of generalized "latent" osteopathy was found in both Ps and PA patients.
    • This osteopathy is characterized by an elevated bone turnover rate with preserved bone volume (high turnover remodeling).
    • No significant difference in bone turnover was observed between Ps and PA groups.

    Conclusions:

    • The findings support the existence of a generalized "latent" osteopathy in psoriatic disease.
    • Latent vitamin D deficiency and/or vitamin D hormone resistance are discussed as potential shared pathogenetic factors.
    • This highlights a potential link between dermatosis and bone alterations in psoriatic patients.