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Long-term outcome of Tako-tsubo cardiomyopathy

Costin N Ionescu1, Cesar A Aguilar-Lopez, Antoine E Sakr

  • 1Section of Cardiology, Hospital of Saint Raphael, New Haven, Connecticut 06511, United States. cionescu@srhs.org

Heart, Lung & Circulation
|July 27, 2010
PubMed

Insights

Tako-tsubo cardiomyopathy (TC) outcomes are worse than previously thought, with over half of patients experiencing adverse events. Myocardial perfusion grade does not predict outcomes in TC patients.

Area of Science:

  • Cardiology
  • Cardiovascular Research

Background:

  • Tako-tsubo cardiomyopathy (TC) is often associated with an excellent patient outcome.
  • However, recent findings suggest a need to re-evaluate the long-term prognosis of TC.

Purpose of the Study:

  • To assess the long-term outcome of patients diagnosed with TC.
  • To determine the prognostic significance of thrombolysis in myocardial infarction myocardial perfusion grade (TMPG) in TC patients.

Main Methods:

  • A retrospective analysis was conducted on all patients diagnosed with TC between 2003 and 2008.
  • Data from 27 TC patients were analyzed, with a mean follow-up of 27 months.

Main Results:

  • Over half of TC patients (52%) experienced a combined endpoint including death, cardiogenic shock, sudden cardiac death, or cardiac rehospitalization.
  • Abnormal TMPG was observed in 37% of cases, but it did not correlate with patient outcomes.
  • The study population predominantly consisted of postmenopausal Caucasian females (96%).

Conclusions:

  • The long-term outcome for patients with TC is poorer than previously reported.
  • TMPG is not a reliable predictor of outcomes in patients with TC.
Abstract

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