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Comparative study of non-destructive methods to quantify thickness of tablet coatings
C Cahyadi1, A D Karande, L W Chan
1GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore.
International Journal of Pharmaceutics
|July 27, 2010
Summary
Raman and near-infrared (NIR) spectroscopy offer rapid, non-destructive methods for tablet coating thickness evaluation. Raman spectroscopy accurately differentiates coatings applied under varying conditions, complementing direct measurements.
Area of Science:
- Pharmaceutical Technology
- Analytical Chemistry
- Process Engineering
Background:
- The Supercell coater, a novel air fluidization tablet coating system, requires precise coat thickness quantification.
- Developing fast, non-destructive methods is crucial for process control and quality assurance in tablet coating.
Purpose of the Study:
- To establish a rapid and non-destructive method for quantifying coat thickness on Supercell-coated tablets.
- To compare the efficacy of various analytical techniques for coat thickness assessment.
Main Methods:
- Tablets were coated under diverse process conditions.
- Coat thickness was measured using optical microscopy, micrometer, X-ray fluorescence (XRF), Raman, and near-infrared (NIR) spectroscopy.
- Spectroscopic data were calibrated using direct thickness measurements for model development and validation.
Main Results:
- XRF spectroscopy is suitable for process yield and efficiency assessment.
- Raman and NIR spectroscopy provide rapid coat thickness prediction, with Raman offering superior differentiation of coatings from varied conditions.
- Direct measurements ensure accurate thickness data but are time-consuming.
Conclusions:
- Raman and NIR spectroscopy are effective, rapid alternatives for tablet coating thickness evaluation.
- Raman spectroscopy demonstrates high accuracy in distinguishing between different coating process outcomes.
- Spectroscopic methods offer complementary data for comprehensive tablet coating analysis.
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