Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mitosis and Cytokinesis

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

Mitosis and Cytokinesis

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

Determining the Plane of Cell Division

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

Mitosis and Cytokinesis

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

Determining the Plane of Cell Division

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

Mitosis And Cytokinesis

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast.

bioRxiv : the preprint server for biology·2026

Same author

Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle.

Nature communications·2025

Same author

Fission yeast Pdk1 kinase regulates cytokinesis and eisosomes.

Molecular biology of the cell·2025

Same author

Fission yeast Pdk1 kinase regulates cytokinesis and eisosomes.

bioRxiv : the preprint server for biology·2025

Same author

Spatiotemporal orchestration of mitosis by cyclin-dependent kinase.

Nature·2025

Same author

Science, Education, Leadership, and Politics: An Interview with Bruce Alberts and Paul Nurse.

Annual review of cell and developmental biology·2025

Search research articles

Related Experiment Video

Updated: May 12, 2026

Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

Published on: December 3, 2010

Cell division intersects with cell geometry.

James B Moseley¹, Paul Nurse

¹The Rockefeller University, New York, NY 10065, USA. jmoseley@rockefeller.edu

|July 27, 2010

Summary

Single-celled organisms sense cell shape to regulate cell division timing and chromosome segregation. This geometry-sensing links cell division control with ensuring proper DNA distribution.

Area of Science:

Cell Biology
Microbiology
Genetics

Background:

Single-celled organisms possess sophisticated mechanisms to monitor their physical environment.
Cell geometry plays a crucial role in regulating fundamental cellular processes like division.

Purpose of the Study:

To investigate how single-celled organisms utilize cell geometry information.
To understand the link between geometry sensing and the control of cell division and chromosome segregation.

Main Methods:

Observational studies on single-celled organisms.
Analysis of cellular geometry sensing pathways.
Investigation of the connection between cell division control and chromosome segregation machinery.

Main Results:

More Related Videos

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Published on: October 21, 2015

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Published on: November 29, 2017

Related Experiment Videos

Last Updated: May 12, 2026

Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

Published on: December 3, 2010

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Published on: October 21, 2015

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Published on: November 29, 2017

Cell geometry is actively monitored by single-celled organisms.
Geometry-sensing mechanisms influence both the initiation of cell division and the orientation of chromosome segregation.
A potential link exists between signals governing cell division and those ensuring accurate chromosome segregation.

Conclusions:

Cell geometry is a key factor in regulating cell division in unicellular organisms.
Geometry sensing is integrated with chromosome segregation processes.
Further research is warranted to elucidate the precise signaling pathways connecting cell geometry to cell division and segregation.