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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 14, 2026

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur
07:33

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Published on: November 14, 2017

No bones about it: insulin modulates skeletal remodeling.

Clifford J Rosen1, Katherine J Motyl

  • 1Maine Medical Center Research Institute, Scarborough, ME 04074, USA. rosenc@mmc.org

Cell
|July 27, 2010
PubMed
Summary

Insulin signaling boosts bone formation by activating osteoblasts and increasing osteocalcin, a key mediator of insulin sensitivity. This discovery links bone remodeling directly to metabolic homeostasis.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Homeostasis

Background:

  • Bone remodeling is a continuous process involving bone resorption and formation.
  • Metabolic homeostasis is crucial for overall health and is regulated by various hormones.
  • The interplay between bone metabolism and systemic metabolic regulation is an emerging area of research.

Discussion:

  • This research investigates the role of insulin signaling in bone remodeling.
  • It explores how insulin influences osteoblast activity and osteocalcin production.
  • The study examines the connection between bone resorption and insulin sensitivity.

Key Insights:

  • Insulin signaling directly promotes the activation of bone-forming osteoblasts.
  • Insulin enhances the production of osteocalcin, a mediator of insulin sensitivity.

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Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
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Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

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Related Experiment Videos

Last Updated: May 14, 2026

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur
07:33

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Published on: November 14, 2017

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
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A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
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Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

  • Bone resorption is modulated by insulin signaling, impacting metabolic homeostasis.

    • Outlook:

    • Further research can elucidate the precise molecular mechanisms linking insulin and bone.
    • This understanding may lead to novel therapeutic strategies for metabolic disorders and bone diseases.
    • Investigating osteocalcin's role could reveal new targets for improving insulin sensitivity.