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Calcium and energy: making the cake and eating it too?
Douglas R Green1, Ruoning Wang
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 92105, USA. douglas.green@stjude.org
Cell
|July 27, 2010
Abstract:
Mitochondrial calcium ions promote a number of events that sustain ATP levels in the cell. Cardenas et al. (2010) now demonstrate that the inositol 1,4,5-triphosphate receptor at the endoplasmic reticulum constitutively provides calcium for mitochondria. In the absence of this calcium transfer, cells use autophagy to sustain survival.
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