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Related Concept Videos

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Depression: Overview01:18

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
G Protein-coupled Receptors01:15

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
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Related Experiment Video

Updated: Jun 10, 2026

BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABAA Receptor Presentation in the Rodent Brain
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GABAB receptors and depression. Current status.

John F Cryan1, David A Slattery

  • 1School of Pharmacy, Department of Pharmacology & Therapeutics, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.

Advances in Pharmacology (San Diego, Calif.)
|July 27, 2010
PubMed
Summary

Blocking gamma-aminobutyric acid (GABA) B receptors may offer a novel antidepressant treatment. Research indicates GABA B receptor antagonists produce antidepressant-like effects, potentially through interactions with serotonin and BDNF pathways.

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Published on: September 23, 2021

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Gamma-aminobutyric acid (GABA) system dysfunction is implicated in psychiatric disorders.
  • GABA(A) receptors are linked to anxiety, but GABA's role in depression is less clear.
  • GABA(B) receptors' involvement in depression etiology was historically difficult to study due to a lack of selective compounds.

Purpose of the Study:

  • To explore the role of GABA(B) receptors in depression.
  • To assess the potential of GABA(B) receptor antagonists as antidepressant agents.

Main Methods:

  • Review of recent behavioral studies using selective GABA(B) receptor antagonists.
  • Examination of data from knockout mice models.
  • Analysis of literature on GABA system interactions with other neurobiological factors.

Main Results:

  • Blockade or loss of function of GABA(B) receptors appears to induce an antidepressant-like phenotype.
  • GABA(B) receptor system interacts significantly with the serotonergic system and brain-derived neurotrophic factor (BDNF).
  • Clinical studies show altered GABA levels, but direct assessment of GABA(B) receptors is limited.

Conclusions:

  • GABA(B) receptor antagonists may possess antidepressant properties, potentially mediated by interactions with serotonin and BDNF.
  • Further research, including clinical studies targeting GABA(B) receptors, is warranted.
  • GABA(B) receptor antagonists could represent a new class of antidepressant medications.