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Related Concept Videos

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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Related Experiment Video

Updated: Jun 10, 2026

Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals
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Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals

Published on: October 31, 2011

Bead-based optical fiber arrays for artificial olfaction.

David R Walt1

  • 1Tufts University, Department of Chemistry, Medford, MA 02155, USA. david.walt@tufts.edu

Current Opinion in Chemical Biology
|July 27, 2010
PubMed
Summary

Recent advances in bead-based optical sensor arrays offer improved vapor sensing. These fluorescent microsphere sensors overcome limitations of older olfactory system-based sensors for diverse applications.

Area of Science:

  • Optoelectronics
  • Chemical Sensing
  • Biomimetic Systems

Background:

  • Mammalian olfactory system-based sensor arrays have been used for decades.
  • Previous sensor technologies faced challenges in reproducibility, training, and sensitivity.
  • These limitations restricted their use to specialized applications.

Purpose of the Study:

  • To review recent advancements in bead-based optical sensor arrays for vapor sensing.
  • To highlight how these novel sensors address limitations of prior technologies.
  • To discuss the potential applications and research directions for these advanced sensors.

Main Methods:

  • Utilizing fluorescent microspheres to create optical sensor arrays.
  • Leveraging spectral and temporal responses for data acquisition.

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  • Employing signal summation for enhanced sensitivity.
  • Developing portable instrumentation for field deployment.

    • Main Results:

    • Optical sensor arrays based on fluorescent microspheres demonstrate improved performance.
    • These arrays provide information-rich spectral and temporal data for vapor identification.
    • Enhanced sensitivity is achievable through summed sensor responses.
    • Portable systems facilitate practical field applications.

    Conclusions:

    • Bead-based optical sensor arrays represent a significant advancement in vapor sensing technology.
    • These sensors offer solutions to the reproducibility, training, and sensitivity issues of older systems.
    • The technology holds promise for both practical field applications and fundamental research into biological olfaction.