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Related Experiment Video

Updated: Jun 10, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-beta1 decrease rabbit

Huilin Yang1, Jian Wu, Jiayong Liu

  • 1The First Affiliated Hospital of Suzhou University, Suzhou 215006, China.

The Spine Journal : Official Journal of the North American Spine Society
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

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Mesenchymal stem cells (MSCs) slow disc degeneration and preserve disc height index (DHI) by inhibiting apoptosis. This study shows MSC transplantation is a promising treatment for low back pain.

Area of Science:

  • Regenerative Medicine
  • Orthopedics
  • Stem Cell Biology

Background:

  • Disc degeneration is a primary cause of low back pain, often linked to apoptosis.
  • Mesenchymal stem cells (MSCs) show potential in treating disc degeneration by differentiating into nucleus pulposus cells.
  • The impact of MSC transplantation on disc height index (DHI) and apoptosis inhibition requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of MSC transplantation in improving DHI.
  • To assess the potential of MSCs to inhibit apoptosis in a disc degeneration model.
  • To explore MSCs as a therapeutic strategy for low back pain.

Main Methods:

  • A randomized, controlled animal study involving 54 rabbits with induced disc degeneration.

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Published on: August 2, 2022

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Last Updated: Jun 10, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Isolation, Expansion, and Differentiation of Mesenchymal Stem Cells from the Infrapatellar Fat Pad of the Goat Stifle Joint
12:06

Isolation, Expansion, and Differentiation of Mesenchymal Stem Cells from the Infrapatellar Fat Pad of the Goat Stifle Joint

Published on: August 2, 2022

  • Groups included a degenerative model, PFG-TGF-beta1 transplantation, and MSC-PFG-TGF-beta1 transplantation.
  • Evaluations used computed radiography, MRI, and histological examinations at 4, 8, and 12 weeks.

    • Main Results:

    • MSC transplantation inhibited apoptosis and slowed the decrease in DHI.
    • MRI revealed less degeneration and a slower DHI decrease in the MSC group compared to controls.
    • The MSC group showed increased nucleus pulposus and type II collagen, with reduced apoptosis.

    Conclusions:

    • Mesenchymal stem cells effectively slow the rate of DHI decrease in degenerated discs.
    • MSC-mediated apoptosis inhibition is a key mechanism for preserving disc structure and function.
    • MSC transplantation offers a potential therapeutic approach for managing low back pain associated with disc degeneration.