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Related Concept Videos

The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Gross Anatomy of Bone01:17

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...

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Related Experiment Video

Updated: Jun 10, 2026

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

Bone and bone marrow: the same organ.

Andrea Del Fattore1, Marta Capannolo, Nadia Rucci

  • 1Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy. andrea.delf@gmail.com

Archives of Biochemistry and Biophysics
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Bone and bone marrow form a single functional unit, the bone-bone marrow organ. Their close relationship means diseases affecting one commonly impact the other, highlighting their interdependence.

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Last Updated: Jun 10, 2026

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Tracking Mouse Bone Marrow Monocytes In Vivo
12:08

Tracking Mouse Bone Marrow Monocytes In Vivo

Published on: February 27, 2015

Area of Science:

  • Bone Biology
  • Hematology
  • Cell Biology

Background:

  • Bone and bone marrow exhibit intricate anatomical and functional connections.
  • Bone marrow, located within the medullary cavity, is regulated by bone cells during hematopoiesis.
  • Osteoclasts and osteoblasts originate from hematopoietic and mesenchymal precursors within the bone marrow.

Purpose of the Study:

  • To describe the histological and functional interplays between bone and bone marrow.
  • To illustrate diseases demonstrating the tight correlation between bone and bone marrow.

Main Methods:

  • Histological analysis of bone and bone marrow structures.
  • Functional assessment of cellular interactions.
  • Review of pathological conditions affecting the bone-marrow axis.

Main Results:

  • Evidence of tight functional correlation beyond anatomical connections.
  • Demonstration of reciprocal influence between bone and bone marrow compartments.
  • Identification of diseases where bone-marrow interdependence is clearly manifested.

Conclusions:

  • Bone and bone marrow function as a unified organ, the bone-bone marrow organ.
  • Dysfunction in one component significantly impacts the other.
  • Understanding this interdependence is crucial for diagnosing and treating related diseases.