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Updated: Jun 10, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Endogenous carbon monoxide production in disease
1National Center for Environmental Assessment, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Mailcode B-243-01, Research Triangle Park, NC 27711, USA. owens.beth@epa.gov
Abstract:
Carbon monoxide (CO) in tissues and cells can originate from inhalation of CO or endogenously. Endogenous production, carboxyhemoglobin (COHb) formation, and exhaled CO levels are influenced by physiological factors, including disease. It is suggested that endogenous CO production can be used as a biomarker for oxidative and inflammatory processes. Also, endogenous CO can contribute to increased body burden of CO, which may both disrupt normal CO signaling cascades and increase the risk of CO toxicity.
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