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Related Experiment Video

Updated: Jan 19, 2026

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

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TERRA biogenesis, turnover and implications for function.

Sascha Feuerhahn1, Nahid Iglesias, Andrea Panza

  • 1Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

FEBS Letters
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Telomeres transcribe into TERRA, a long non-coding RNA found in heterochromatin and nucleoplasm. This review covers TERRA

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Area of Science:

  • * Molecular Biology
  • * Genetics
  • * RNA Biology

Background:

  • * Telomeres, heterochromatic structures at chromosome ends, are transcribed.
  • * This transcription yields TERRA (Telomeric Repeat-containing RNA), a long non-coding RNA.
  • * Telomere transcription is conserved across eukaryotic kingdoms.

Purpose of the Study:

  • * To review current knowledge on TERRA structure, biogenesis, and turnover.
  • * To discuss the presumed roles of TERRA in cellular processes.

Main Methods:

  • * Literature review of existing studies on TERRA.
  • * Synthesis of data on TERRA's molecular characteristics and functions.

Main Results:

  • * TERRA is a component of telomeric heterochromatin and the nucleoplasm.
  • * Telomere transcription into TERRA is a widespread eukaryotic phenomenon.
  • * TERRA is implicated in telomeric DNA replication, heterochromatin formation, and telomerase regulation.

Conclusions:

  • * TERRA is a key player in telomere biology.
  • * Further research is needed to fully elucidate TERRA's functions in regulating telomere maintenance and gene expression.