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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

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Published on: February 19, 2016

Layer-by-layer surface modification of lipid nanocapsules.

Samuli Hirsjärvi¹, Yan Qiao, Audrey Royere

¹Inserm U646, University of Angers, Angers, France. samuli.hirsjarvi@univ-angers.fr

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|July 27, 2010

Summary

This study details surface modification of lipid nanocapsules (LNCs) using layer-by-layer assembly of polyelectrolytes. The modified LNCs show potential for therapeutic applications, demonstrated by incorporating fondaparinux sodium.

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Area of Science:

Nanotechnology
Materials Science
Biomedical Engineering

Background:

Lipid nanocapsules (LNCs) are versatile nanocarriers.
Surface modification is crucial for targeted delivery and therapeutic efficacy.
Layer-by-layer (LBL) assembly offers precise control over nanoparticle coatings.

Purpose of the Study:

To develop a novel surface modification strategy for LNCs.
To investigate the electrostatic adsorption of polyelectrolytes on LNCs.
To explore the potential of functionalized LNCs for drug delivery.

Main Methods:

Sequential adsorption of dextran sulfate (DS) and chitosan (CS) onto LNCs via LBL approach.
Synthesis of cationic lipochitosan (LC) for initial LNC surface modification.

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Utilisation of tangential flow filtration (TFF) for purification during LBL process.

Incorporation of fondaparinux sodium (FP) for therapeutic evaluation.

Main Results:

Successful sequential adsorption of polyelectrolytes demonstrated by alternating zeta potential and increased particle size.
Lipochitosan (LC) effectively modified the LNC surface via post-insertion.
The LBL approach enabled controlled surface functionalization of LNCs.
Fondaparinux sodium (FP) was successfully introduced onto the LNC surface.

Conclusions:

The LBL method provides effective surface functionalization of LNCs.
The developed LNCs are suitable for incorporating therapeutic agents like fondaparinux sodium.
This approach holds promise for developing advanced nanomedicines.