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Related Experiment Video

Updated: Jun 10, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Drug-induced lupus: an update.

Uriel Katz¹, Gisele Zandman-Goddard

¹Immunology and Allergy Unit, Wolfson Medical Center, Holon, Israel.

Autoimmunity Reviews

|July 27, 2010

Summary

Drug-induced lupus (DIL) can present atypically with anti-TNF therapy, showing distinct symptoms and antibody profiles compared to traditional DIL. This suggests a unique form or unmasking of latent lupus.

Area of Science:

Rheumatology
Immunology
Pharmacology

Background:

Drug-induced lupus (DIL) is an autoimmune condition mimicking systemic lupus erythematosus (SLE).
Traditional DIL is associated with drugs like procainamide and hydralazine.
Recent reports indicate DIL can arise from anti-tumor necrosis factor (anti-TNF) biologic therapies.

Purpose of the Study:

To review and update the understanding of drug-induced lupus (DIL).
To specifically emphasize the characteristics of anti-TNF-induced lupus.

Main Methods:

Literature review and analysis of reported cases.
Comparison of clinical and serological features of anti-TNF-induced DIL with classical DIL and idiopathic SLE.

Main Results:

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Published on: November 1, 2015

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Anti-TNF-induced DIL can manifest with classic SLE dermatologic symptoms.
Cases show hypocomplementemia and increased anti-double-stranded DNA (anti-dsDNA) antibody titers.
A decreased incidence of anti-histone antibodies was observed in anti-TNF-induced DIL.

Conclusions:

Anti-TNF-induced DIL may represent a distinct clinical entity.
Alternatively, it could unmask a pre-existing, latent idiopathic SLE.