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Updated: Jun 10, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
Published on: November 9, 2020
Fragment-based discovery and optimization of BACE1 inhibitors
James Madden1, Jenny R Dod, Robert Godemann
1Evotec UK Ltd, Abingdon, UK. james.madden@evotec.com
Abstract:
A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed.
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